Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis

被引：953

作者：

Iliev, Iliyan D. ^{[1
]}

Funari, Vincent A. ^{[2
,3
]}

Taylor, Kent D. ^{[2
]}

Quoclinh Nguyen ^{[2
]}

Reyes, Christopher N. ^{[1
]}

Strom, Samuel P. ^{[2
]}

Brown, Jordan ^{[2
]}

Becker, Courtney A. ^{[1
]}

Fleshner, Phillip R. ^{[4
]}

Dubinsky, Marla ^{[1
,5
]}

Rotter, Jerome I. ^{[2
]}

Wang, Hanlin L. ^{[6
]}

McGovern, Dermot P. B. ^{[1
,2
]}

Brown, Gordon D. ^{[7
,8
]}

Underhill, David M. ^{[1
,6
,9
]}

机构：

[1] Cedars Sinai Med Ctr, Inflammatory Bowel & Immunobiol Res Inst, Los Angeles, CA 90048 USA

[2] Cedars Sinai Med Ctr, Inst Med Genet, Los Angeles, CA 90048 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Los Angeles, CA 90095 USA

[4] Cedars Sinai Med Ctr, Dept Surg, Los Angeles, CA 90048 USA

[5] Cedars Sinai Med Ctr, Dept Pediat, Los Angeles, CA 90048 USA

[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[7] Univ Aberdeen, Inst Med Sci, Div Appl Med, Sect Immunol & Infect, Aberdeen AB24 2ZD, Scotland

[8] Univ Aberdeen, Aberdeen Fungal Grp, Aberdeen AB24 2ZD, Scotland

[9] Cedars Sinai Med Ctr, Div Immunol Res, Los Angeles, CA 90048 USA

来源：

SCIENCE | 2012年 / 336卷 / 6086期

基金：

英国惠康基金;

关键词：

GENOME-WIDE ASSOCIATION; CANDIDA-ALBICANS; GUT MICROBIOTA; INDUCTION; SUSCEPTIBILITY; RECOGNITION; RESPONSES; CELLS; MICE;

D O I：

10.1126/science.1221789

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich fungal community that interacts with the immune system through the innate immune receptor Dectin-1. Mice lacking Dectin-1 exhibited increased susceptibility to chemically induced colitis, which was the result of altered responses to indigenous fungi. In humans, we identified a polymorphism in the gene for Dectin-1 (CLEC7A) that is strongly linked to a severe form of ulcerative colitis. Together, our findings reveal a eukaryotic fungal community in the gut (the "mycobiome") that coexists with bacteria and substantially expands the repertoire of organisms interacting with the intestinal immune system to influence health and disease.

引用

页码：1314 / 1317

页数：4

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