Submolecular resolution of single macromolecules with atomic force microscopy

被引：73

作者：

Czajkowsky, DM

Shao, ZF ^{[1
]}

机构：

[1] Univ Virginia, Sch Med, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA

[2] Univ Virginia, Sch Med, Biophys Program, Charlottesville, VA 22908 USA

来源：

FEBS LETTERS | 1998年 / 430卷 / 1-2期

关键词：

atomic force microscopy; individual molecule; structure; imaging methods;

D O I：

10.1016/S0014-5793(98)00461-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The intrinsically high signal-to-noise ratio of atomic force microscopy (AFM) permits structural determination of individual macromolecules to, at times, subnanometer resolution directly from unprocessed images, avoiding the conditions and possible consequences of averaging over an ensemble of molecules. In this article, we will review some of the most recent achievements in imaging single macromolecules with AFM. (C) 1998 Federation of European Biochemical Societies.

引用

页码：51 / 54

页数：4

共 39 条

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