Anti-Markovnikov intermolecular hydroamination: A bis(amidate) titanium precatalyst for the preparation of reactive aldimines

被引：149

作者：

Zhang, Z ^{[1
]}

Schafer, LL ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 24期

关键词：

D O I：

10.1021/ol0359214

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A bulky bis(N-2',6'-diisopropylphenyi(phenyl)-amidate)titanium-bis(diethylamido) complex was identified as a highly active and regloselective precatalyst for the anti-Markovnikov hydroamination of a wide range of terminal alkyl alkynes; with alkylamines. This titanium complex was fully characterized, including its X-ray crystal structure. The reactive aldimine products generated have been further elaborated using one-pot procedures to give substituted amines, aidehydes, and the isoquinoline framework.

引用

页码：4733 / 4736

页数：4

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