RNA-polymerase-I-directed rDNA transcription, life and works

被引：223

作者：

Russell, J ^{[1
]}

Zomerdijk, JCBM ^{[1
]}

机构：

[1] Univ Dundee, Div Gene Regulat & Express, Wellcome Trust Bioctr, Dundee DD1 5EH, Scotland

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2005年 / 30卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.tibs.2004.12.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the extensive network of interdependent biochemical processes required for cell growth and division, there is mounting evidence that ribosomal DNA transcription by RNA polymerase I (pol I) not only drives cell growth via its direct role in production of the ribosomal RNA (rRNA) component of the protein-synthesis machinery, but that it is also crucial in determining the fate of the cell. Considerable progress has been made in recent years towards understanding both the function of components of the pol I transcription machinery and how cells accomplish the tight control of pol I transcription, balancing the supply of rRNA with demand under different growth conditions.

引用

页码：87 / 96

页数：10

共 90 条

[61]

REEDER RH, 1995, NUCL ACIDS MOL BIOL, V9, P251

[62] Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses [J].