Allylic protection of thiols and cysteine.: III.: Use of Fmoc-Cys(Fsam)-OH for solid-phase peptide synthesis

被引：1

作者：

Gomez-Martinez, P

Guibé, F

Albericio, F

机构：

[1] Univ Paris Sud, Inst Chim Mol Orsay, Lab Catalyse Mol, UPRESA 8075, F-91405 Orsay, France

[2] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain

来源：

LETTERS IN PEPTIDE SCIENCE | 2000年 / 7卷 / 04期

关键词：

cystine; disulfide formation; Pdchemistry; protecting group;

D O I：

10.1007/BF02447857

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The solid-phase synthesis of peptides containing Cys has been carried out using the new thiol protecting group Fsam, which is completely stable to basic and acidic conditions used in both main strategies and can be selectively removed by palladium-catalyzed allylic cleavage in the presence of nucleophiles. This protecting group adds a new dimension of orthogonality for regioselective cysteine pairing strategies.

引用

页码：187 / 194

页数：8

共 23 条

[21] Tandem deprotection-coupling of Nα-Alloc-amino acids by use of ternary systems Pd cat./PhSiH3/carboxy-activated amino acid [J].