Mediator - a universal complex in transcriptional regulation

被引：28

作者：

Gustafsson, CM ^{[1
]}

Samuelsson, T

机构：

[1] Karolinska Inst, Novum, Dept Med Nutr, S-14186 Huddinge, Sweden

[2] Gothenburg Univ, Dept Med Biochem, S-41390 Gothenburg, Sweden

来源：

MOLECULAR MICROBIOLOGY | 2001年 / 41卷 / 01期

关键词：

D O I：

10.1046/j.1365-2958.2001.02481.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Mediator complex is essential for basal and regulated expression of nearly all RNA polymerase II-dependent genes in the Saccharomyces cerevisiae genome. Mediator acts as a bridge, conveying regulatory information from enhancers and other control elements to the promoter. It is now clear that Mediator-like complexes also exist in higher eukaryotic cells and that they have an important role in metazoan transcriptional regulation. However, the exact mechanism of Mediator-dependent transcriptional regulation remains unclear. We review here some recent advances in our understanding of Mediator structure and function. We also discuss a model to account for the functional and evolutionary relationship between yeast and metazoan Mediators. As an appendix to this review, we have created a database, MEDB, in which we have compiled information about all the S. cerevisiae Mediator subunits and their homologues in other eukaryotic cells.

引用

页码：1 / 8

页数：8

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