pain1:: A neuropathic pain QTL on mouse chromosome 15 in a C3H X C58 backcross

被引：30

作者：

Devor, M

Gilad, A

Arbilly, M

Yakir, B

Raber, P

Pisanté, A

Darvasi, A ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Dept Genet, Inst Life Sci, IL-91904 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Dept Cell & Anim Biol, IL-91904 Jerusalem, Israel

[3] Hebrew Univ Jerusalem, Ctr Res Pain, Inst Life Sci, IL-91904 Jerusalem, Israel

[4] Hebrew Univ Jerusalem, Dept Stat, IL-91904 Jerusalem, Israel

来源：

PAIN | 2005年 / 116卷 / 03期

基金：

以色列科学基金会;

关键词：

autotomy; QTL; neuropathic pain; pain gene;

D O I：

10.1016/j.pain.2005.04.023

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

We have produced a backcross (BC) population of 267 mice from the parental strains C3H/HeN and C58/J. The mice were phenotyped for neuropathic pain using the neuroma model. Subsequently all BC mice were genotyped in a region of chromosome 15 that has been previously suggested to contain a quantitative trait locus (QTL) for this trait. We have confirmed the linkage of the QTL, named pain1, to the central region of chromosome 15. Our finding provides the necessary robustness to justify efforts towards identification of the underlying gene. (c) 2005 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

引用

页码：289 / 293

页数：5

共 31 条

[1] BACK PAIN - A STUDY OF TWINS [J].