Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity

被引：12

作者：

Gardner, JR

Hess, CP

Webb, AG

Tsika, RW

Dawson, MJ

Gulani, V

机构：

[1] Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA

[2] Univ Illinois, Coll Med, Urbana, IL 61801 USA

[3] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA

[4] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA

[5] Univ Missouri, Dept Vet Biomed Sci, Columbia, MO 65211 USA

[6] Univ Illinois, Biomed Magnet Resonance Lab, Urbana, IL 61801 USA

来源：

MAGNETIC RESONANCE IN MEDICINE | 2001年 / 45卷 / 06期

关键词：

MR microscopy; hindlimb suspension; mouse tibial trabecular bone;

D O I：

10.1002/mrm.1148

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

This work describes the use of magnetic resonance (MR) microscopy to examine changes in tibial trabecular bone structure in mice following 28 days of hindlimb suspension, a model simulating the effects of microgravity in rodents. In this first MR study involving mice, analysis of 3D images showed that apparent bone volume fraction, trabecular number, and trabecular thickness were decreased, and apparent trabecular spacing increased, significantly (P < 0.05) in hindlimb-suspended mice compared to controls. These changes agreed well with light microcopy measurements from an independent study and also with actual spaceflight experiments with rats. (C) 2001 Wiley-Liss, Inc.

引用

页码：1122 / 1125

页数：4

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