Caffeic acid and cinnamic acid ameliorate glucose metabolism via modulating glycogenesis and gluconeogenesis in insulin-resistant mouse hepatocytes

被引：57

作者：

Huang, Da-Wei ^{[2
]}

Shen, Szu-Chuan ^{[1
]}

机构：

[1] Natl Taiwan Normal Univ, Dept Human Dev & Family Studies, Taipei 10610, Taiwan

[2] Natl Taiwan Univ, Grad Inst Food Sci & Technol, Taipei 10672, Taiwan

来源：

JOURNAL OF FUNCTIONAL FOODS | 2012年 / 4卷 / 01期

关键词：

Caffeic acid; Cinnamic acid; Glucose metabolism; Glycogenesis; Gluconeogenesis; Insulin-resistant; GENE-EXPRESSION; POTENTIAL ROLE; LIVER-CELLS; ALPHA(1A)-ADRENOCEPTORS; PHOSPHORYLATION; GLUCOKINASE; MECHANISMS; SYNTHASE;

D O I：

10.1016/j.jff.2012.01.005

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Tumour necrosis factor-alpha (TNF-alpha) plays a pivotal role in cellular insulin resistance and can induce insulin resistance in mouse FL83B hepatocytes. Caffeic acid and cinnamic acid were found to improve glucose uptake in TNF-alpha-treated insulin-resistant mouse FL83B hepatocytes. The mechanism of glucose metabolism by caffeic acid and cinnamic acid was further investigated. The result from Western blot analysis revealed that caffeic acid and cinnamic acid increased expression of glycogen synthase, whereas the expression of glycogen synthase kinase and phosphorylation of glycogen synthase at Ser641 in insulin-resistant mouse hepatocytes was decreased. Caffeic acid and cinnamic acid suppressed the expression of hepatic nuclear factor-4 in TNF-alpha-treated mouse FL83B hepatocytes. The activity of phosphoenolpyruvate carboxykinase was also inhibited. Thus, caffeic acid and cinnamic acid ameliorated glucose metabolism by promoting glycogenesis and inhibiting gluconeogenesis in TNF-alpha-treated insulin-resistant mouse hepatocytes. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：358 / 366

页数：9

共 28 条

[1] Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle [J].

Bouskila, Michale ;

Hirshman, Michael F. ;

Jensen, Jorgen ;

Goodyear, Laurie J. ;

Sakamoto, Kei .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2008, 294 (01) :E28-E35

[2] Stimulatory effect of cinnamic acid analogues on α1A-adrenoceptors in-vitro [J].

Chang, HK ;

Hsu, FL ;

Liu, IM ;

Cheng, JT .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2003, 55 (06) :833-837

[3] A cell-based screening identifies compounds from the stem of Momordica charantia that overcome insulin resistance and activate AMP-activated protein kinase [J].

Cheng, Hsueh-Ling ;

Huang, Hsin-Kai ;

Chang, Chi-I ;

Tsai, Chung-Pao ;

Chou, Chang-Hung .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (16) :6835-6843

[4] Stimulatory effect of caffeic acid on α1A-adrenoceptors to increase glucose uptake into cultured C2C12 cells [J].

Cheng, JT ;

Liu, IM .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2000, 362 (02) :122-127

[5] Protein kinase B/Akt mediates effects of insulin on hepatic insulin-like growth factor-binding protein-1 gene expression through a conserved insulin response sequence [J].

Cichy, SB ;

Uddin, S ;

Danilkovich, A ;

Guo, SD ;

Klippel, A ;

Unterman, TG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (11) :6482-6487

[6] Correction of diabetic alterations by glucokinase [J].

Ferre, T ;

Pujol, A ;

Riu, E ;

Bosch, F ;

Valera, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (14) :7225-7230

[7] Control of glycogen deposition [J].

Ferrer, JC ;

Favre, C ;

Gomis, RR ;

Fernández-Novell, JM ;

García-Rocha, M ;

de la Iglesia, N ;

Cid, E ;

Guinovart, JJ .

FEBS LETTERS, 2003, 546 (01) :127-132

[8] Molecular cloning and functional expression of the guinea pig α1a-adrenoceptor [J].

González-Espinosa, C ;

Romero-Avila, MT ;

Mora-Rodríguez, DM ;

González-Espinosa, D ;

García-Sáinz, JA .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2001, 426 (03) :147-155

[9] Seasonal change and prolonged anoxia affect the kinetic properties of phosphofructokinase and pyruvate kinase in oysters [J].

Greenway, SC ;

Storey, KB .

JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY, 2000, 170 (04) :285-293

[10] Effects of Caffeic Acid and Cinnamic Acid on Glucose Uptake in Insulin-Resistant Mouse Hepatocytes [J].

Huang, Da-Wei ;

Shen, Szu-Chuan ;

Wu, James Swi-Bea .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2009, 57 (17) :7687-7692

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