Effects of Caffeic Acid and Cinnamic Acid on Glucose Uptake in Insulin-Resistant Mouse Hepatocytes

被引：87

作者：

Huang, Da-Wei ^{[1
]}

Shen, Szu-Chuan ^{[2
]}

Wu, James Swi-Bea ^{[1
]}

机构：

[1] Natl Taiwan Univ, Coll Bioresources & Agr, Grad Inst Food Sci & Technol, Taipei 106, Taiwan

[2] I Shou Univ, Coll Med, Dept Med Nutr, Kaohsiung 840, Taiwan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2009年 / 57卷 / 17期

关键词：

Diabetes mellitus; caffeic acid; cinnamic acid; glucose uptake; insulin resistance; NECROSIS-FACTOR-ALPHA; DIABETIC-RATS; FERULIC ACID; C2C12; CELLS; IN-VIVO; METABOLISM; POLYPHENOLS; ACTIVATION; EXPRESSION; RECEPTOR;

D O I：

10.1021/jf901376x

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Tumor necrosis factor-a was used to induce insulin resistance of mouse liver FL83B cells. Two phenolic acids, caffeic acid and cinnamic acid, were then added separately to investigate their effects on glucose uptake of the insulin-resistant cells. The results suggest that these two phenolic acids may promote insulin receptor tyrosyl phosphorylation, up-regulate the expression of insulin signal associated proteins, including insulin receptor, phosphatidylinositol-3 kinase, glycogen synthase, and glucose transporter-2, increase the uptake of glucose, and alleviate insulin resistance in cells as a consequence.

引用

页码：7687 / 7692

页数：6

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