Gankyrin: An intriguing name for a novel regulator of p53 and RB

被引：42

作者：

Lozano, G

Zambetti, GP

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Mol Genet, Sect Canc Genet, Houston, TX 77030 USA

[2] St Jude Childrens Res Hosp, Dept Biochem, Memphis, TN 38105 USA

来源：

CANCER CELL | 2005年 / 8卷 / 01期

关键词：

D O I：

10.1016/j.ccr.2005.06.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The RIB and p53 tumor suppressors lie at the heart of cancer biology, and inactivation of both pathways is seemingly essential for tumor development. Previous studies identified gankyrin as a component of the 26S proteasome that is consistently overexpressed in liver cancer and promotes cell transformation by binding RIB. In the current issue of Cancer Cell, Fujita and colleagues (Higashitsuji et al., 2005) show that gankyrin also binds MDM2 and facilitates its destruction of p53. These important findings implicate gankyrin as a dual-purpose negative regulator of RB and p53, thereby identifying gankyrin as a rational cancer therapeutic target.

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页码：3 / 4

页数：2

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