Isolation, structure elucidation, and antifungal activity of a manumycin-type antibiotic from Streptomyces flaveus

被引：27

作者：

Hwang, BK ^{[1
]}

Lee, JY ^{[1
]}

Kim, BS ^{[1
]}

Moon, SS ^{[1
]}

机构：

[1] KONJU NATL UNIV,DEPT CHEM,KONG JU 314701,SOUTH KOREA

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 1996年 / 44卷 / 11期

关键词：

2,4,6-trimethyldeca-(2E,4E)-dienamide; manumycin; Streptomyces flaveus; antifungal activity;

D O I：

10.1021/jf960084o

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

A manumycin-type antibiotic, SW-B, has been isolated from the solid agar culture of Streptomyces flaveus strain A-11. The structure was determined by mass spectrometry and one- and two-dimensional NMR spectroscopy. SW-B was detected at R(f) 0.5 on the TLC plate developed with chloroform-methanol (90:10 v/v). The UV spectrum of SW-B in methanol showed peaks at 208 and 260 nm. The antibiotic SW-B was confirmed to be a derivative of a manumycin-type antibiotic, 2,4,6-trimethyldeca-(2E,4E)-dienamide (C13H23NO, 209.1780). SW-B showed strong antifungal activity against Phytophthora capsici, Magnaporthe grisea, Cladosporium cucumerinum, and Alternaria mall. However, it lacked antimicrobial activity against yeast and bacteria.

引用

页码：3653 / 3657

页数：5

共 31 条

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