Non-canonical activation of Notch signaling/target genes in vertebrates

被引：74

作者：

Sanalkumar, Rajendran ^{[1
]}

Dhanesh, Sivadasan Bindu ^{[1
]}

James, Jackson ^{[1
]}

机构：

[1] Rajiv Gandhi Ctr Biotechnol, Div Neurobiol, Neuro Stem Cell Biol Lab, Thiruvananthapuram 695014, Kerala, India

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2010年 / 67卷 / 17期

关键词：

Notch signaling; CBF1-independent Notch; Hes-1; Non-canonical Notch; Neural differentiation; Tumorigenesis; NEURAL STEM-CELLS; BHLH TRANSCRIPTION FACTORS; RETINAL PROGENITOR CELLS; RBP-J; NEOPLASTIC TRANSFORMATION; INDEPENDENT PATHWAYS; FATE DETERMINATION; HES-1; EXPRESSION; BINDING PROTEIN; NERVOUS-SYSTEM;

D O I：

10.1007/s00018-010-0391-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evolutionarily conserved Notch signaling orchestrates diverse physiological mechanisms during metazoan development and homeostasis. Classically, ligand-activated Notch receptors transduce the signaling cascade through the interaction of DNA-bound CBF1-co-repressor complex. However, recent reports have demonstrated execution of a CBF1-independent Notch pathway through signaling cross-talks in various cells/tissues. Here, we have tried to congregate the reports that describe the non-canonical/CBF1-independent Notch signaling and target gene activation in vertebrates with specific emphasis on their functional relevance.

引用

页码：2957 / 2968

页数：12

共 106 条

[11] PTF1 is an organ-specific and notch-independent basic helix-loop-helix complex containing the mammalian suppressor of hairless (RBP-J) or its paralogue, RBP-L [J].