New sesquiterpenoid glycoside from the rhizomes of Atractylodes lancea

被引：16

作者：

Long, Liping ^{[1
]}

Wang, Lushan ^{[1
]}

Qi, Shizhou ^{[1
]}

Yang, Yiren ^{[1
]}

Gao, Huiyuan ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2020年 / 34卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Atractylodes lancea; rhizomes; sesquiterpenoids; lignans; absolute configuration; CONSTITUENTS; ROOT;

D O I：

10.1080/14786419.2018.1553170

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Six sesquiterpenoids and four lignans (1-10) were isolated from the n-BuOH extract of the rhizomes of Atractylodes lancea. Among them, the new sesquiterpenoid glycoside named (4 R, 5S, 7R)-hinesolone-11-O-beta-;-glucopyranoside (1), along with three known compounds (2-4) were first obtained from this genus. All the isolates were elucidated by spectroscopic analyses and chemical methods, and the absolute configurations were assigned by electronic circular dichroism spectroscopy technique. In addition, the cytotoxic bioassay of compound 1 was evaluated and results showed it had no significant antitumor activity against human cancer cell lines MCF-7, HepG-2 and Hela.

引用

页码：1138 / 1145

页数：8

共 26 条

[1]

Buske A, 2001, EUR J ORG CHEM, V2001, P3537, DOI 10.1002/1099-0690(200109)2001:18<3537::AID-EJOC3537>3.0.CO

[2]

2-A

[3]

Atractylodin Inhibits Interleukin-6 by Blocking NPM-ALK Activation and MAPKs in HMC-1 [J].