Role of adenomatous polyposis coli (APC) gene mutations in the pathogenesis of colorectal cancer; current status and perspectives

被引：109

作者：

Aghabozorgi, Amirsaeed Sabeti ^{[1
,2
]}

Bahreyni, Amirhossein ^{[3
]}

Soleimani, Atena ^{[4
]}

Bahrami, Afsane ^{[5
]}

Khazaei, Majid ^{[6
]}

Ferns, Gordon A. ^{[7
]}

Avan, Amir ^{[8
,9
]}

Hassanian, Seyed Mahdi ^{[4
,8
]}

机构：

[1] Hormozgan Univ Med Sci, Dept Human Genet, Fac Med, Bandar Abbas, Iran

[2] Hormozgan Univ Med Sci, Student Res Comm, Bandar Abbas, Iran

[3] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran

[4] Mashhad Univ Med Sci, Dept Clin Biochem, Fac Med, Mashhad, Iran

[5] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran

[6] Mashhad Univ Med Sci, Dept Med Physiol, Fac Med, Mashhad, Iran

[7] Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PH, Sussex, England

[8] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran

[9] Mashhad Univ Med Sci, Dept Modern Sci & Technol, Fac Med, Mashhad, Iran

来源：

BIOCHIMIE | 2019年 / 157卷

关键词：

Colorectal cancer; Adenomatous polyposis coli; Wnt signaling pathway; BETA-CATENIN; TUMOR-SUPPRESSOR; DESTRUCTION COMPLEX; CELL-LINES; STEM-CELLS; PATHWAY; VARIANTS; DNA; ASSOCIATION; SENSITIVITY;

D O I：

10.1016/j.biochi.2018.11.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Colorectal cancer (CRC) is one of the most common forms of solid tumors in the world with high rates of mortality and morbidity. Most cases of CRCs are initiated by inactivating mutations in a tumor suppressor gene, adenomatous polyposis coli (APC), leading to constitutive activation of the Wnt signaling pathway. This review summarizes the roles of somatic and germline mutations of the APC gene in hereditary as well as sporadic forms of CRC. We also discuss the diagnostic and prognostic value of the APC gene in the pathogenesis of CRC for a better understanding of CRC disease. (C) 2018 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.

引用

页码：64 / 71

页数：8

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