The metastatic lymph node ratio predicts survival in colon cancer

被引：129

作者：

Schumacher, Paul

Dineen, Sean

Barnett, Carlton, Jr.

Fleming, Jason

Anthony, Thomas

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Surg, Dallas, TX 75390 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Surg, Houston, TX 77030 USA

来源：

AMERICAN JOURNAL OF SURGERY | 2007年 / 194卷 / 06期

关键词：

colon cancer; lymph node ratio; prognosis; survival;

D O I：

10.1016/j.amjsurg.2007.08.030

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: Lymph node metastases are the most important predictor of survival in non-stage IV colon cancer. Recent studies of gastric cancer have shown a prognostic significance of a lymph node ratio (number of positive nodes divided by total number harvested). Our goal was to determine whether a lymph node ratio (LNR) would predict disease-free survival (DFS) and overall survival (OS) in a tertiary care Veterans Affairs medical center. Methods: A retrospective review of a prospectively collected database of colon cancer patients was performed to determine the effect of LNR on DFS and OS. A cohort of 232 patients with non-stage IV colon cancer was eligible for analysis. Survival curves were constructed using the Kaplan-Meier method. Results: For all patients, a LNR of .08 was identified as a breakpoint for predicting OS and DFS. Specific analysis of stage III patients revealed that a LNR of .18 was predictive of DFS. Conclusions: This study showed the prognostic significance of ratio-based staging for colon cancer and may aid in future staging systems. (c) 2007 Excerpta Medica Inc. All rights reserved.

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收藏

页码：827 / 832

页数：6

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