Mechanistic Considerations in the Development and Use of Azine, Diazine and Azole N-Oxides in Palladium-Catalyzed Direct Arylation

被引：120

作者：

Fagnou, Keith ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ottawa, ON K1N 6N5, Canada

来源：

C-H ACTIVATION | 2010年 / 292卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

Direct arylation; Palladium; Catalysis; Azines; Azoles; H BOND ACTIVATION; CROSS-COUPLING REACTIONS; PROTON-ABSTRACTION MECHANISM; ARYL CHLORIDES; NITROGEN-HETEROCYCLES; EFFICIENT CATALYST; BROMIDES; SP(2); ACIDS; FUNCTIONALIZATION;

D O I：

10.1007/128_2009_14

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Azines, diazines or thiazole N-oxides are highly reactive substrates in palladium-catalyzed direct arylation reaction. For these reactions, the results are inconsistent with an SEAr reaction pathway and may best fit with a concerted metalation-deprotonation-like (CMD) mechanism.

引用

收藏

页码：35 / 56

页数：22

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