Common pathogenic mechanisms between depression and epilepsy: an experimental perspective

被引：91

作者：

Jobe, PC ^{[1
]}

机构：

[1] Univ Illinois, Coll Med, Dept Biomed & Therapeut Sci, Peoria, IL 61656 USA

来源：

EPILEPSY & BEHAVIOR | 2003年 / 4卷

关键词：

epilepsy; affective disorder; serotonergic; noradrenergic; anticonvulsants; antidepressants;

D O I：

10.1016/j.yebeh.2003.08.020

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Affective disorders and the epilepsies appear to share partially similar pathogenic mechanisms. Predisposition to both disorders is determined genetically and experientially. A component of the shared predisposition appears to arise from noradrenergic and serotonergic deficits. Shared GABAergic deficits coupled with CRHergic and glutamatergic excesses may trigger and maintain seizures as well as dysfunctional affective episodes, albeit via dissimilar neuronal interplay. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：S14 / S24

页数：11

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