Ten key issues in modern flow chemistry

被引:536
作者
Wegner, Jens
Ceylan, Sascha
Kirschning, Andreas [1 ]
机构
[1] Leibniz Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany
关键词
ORGANIC-SYNTHESIS; MULTICOMPONENT REACTIONS; ELEMENTAL FLUORINE; CHEMICAL-SYNTHESIS; MICROREACTORS; REACTORS; REARRANGEMENT; OPTIMIZATION; DERIVATIVES; OXIDATION;
D O I
10.1039/c0cc05060a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Ten essentials of synthesis in the flow mode, a new enabling technology in organic chemistry, are highlighted as flashlighted providing an insight into current and future issues and developments in this field.
引用
收藏
页码:4583 / 4592
页数:10
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共 81 条
  • [1] Advanced organic synthesis using microreactor technology
    Ahmed-Omer, Batoul
    Brandt, Johan C.
    Wirth, Thomas
    [J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2007, 5 (05) : 733 - 740
  • [2] Catalytic Batch and Continuous Flow Production of Highly Enantioenriched Cyclohexane Derivatives with Polymer-Supported Diarylprolinol Silyl Ethers
    Alza, Esther
    Sayalero, Sonia
    Cambeiro, Xacobe C.
    Martin-Rapun, Rafael
    Miranda, Pedro O.
    Pericas, Miquel A.
    [J]. SYNLETT, 2011, (04) : 464 - 468
  • [3] A Solid-Supported Organocatalyst for Highly Stereoselective, Batch, and Continuous-Flow Mannich Reactions
    Alza, Esther
    Rodriguez-Escrich, Carles
    Sayalero, Sonia
    Bastero, Amaia
    Pericas, Miquel A.
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2009, 15 (39) : 10167 - 10172
  • [4] Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions
    Baumann, Marcus
    Baxendale, Ian R.
    Ley, Steven V.
    Nikbin, Nikzad
    Smith, Christopher D.
    [J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, 6 (09) : 1587 - 1593
  • [5] Development of fluorination methods using continuous-flow microreactors
    Baumann, Marcus
    Baxendale, Ian R.
    Martin, Laetitia J.
    Ley, Steven V.
    [J]. TETRAHEDRON, 2009, 65 (33) : 6611 - 6625
  • [6] Baxendale IR, 2007, ERNST SCHERING FOUND, V3, P151
  • [7] A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly
    Baxendale, Ian R.
    Deeley, Jon
    Griffiths-Jones, Charlotte M.
    Ley, Steven V.
    Saaby, Steen
    Tranmer, Geoffrey K.
    [J]. CHEMICAL COMMUNICATIONS, 2006, (24) : 2566 - 2568
  • [8] Recent advances in multicomponent reactions for diversity-oriented synthesis
    Biggs-Houck, James E.
    Younai, Ashkaan
    Shaw, Jared T.
    [J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2010, 14 (03) : 371 - 382
  • [9] Multicomponent reactions to form heterocycles by microwave-assisted continuous flow organic synthesis
    Bremner, W. Stacy
    Organ, Michael G.
    [J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2007, 9 (01): : 14 - 16
  • [10] Microwave enhanced synthesis
    Caddick, Stephen
    Fitzmaurice, Richard
    [J]. TETRAHEDRON, 2009, 65 (17) : 3325 - 3355