Ribozyme catalysis: not different, just worse

被引：114

作者：

Doudna, JA ^{[1
]}

Lorsch, JR

机构：

[1] Univ Calif Berkeley, Howard Hughes Med Inst, Dept Chem, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[2] Johns Hopkins Univ, Sch Med, Dept Biophys & Biophys Chem, Baltimore, MD 21205 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2005年 / 12卷 / 05期

关键词：

D O I：

10.1038/nsmb932

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evolution has resoundingly favored protein enzymes over RNA-based catalysts, yet ribozymes occupy important niches in modern cell biology that include the starring role in catalysis of protein synthesis on the ribosome. Recent results from structural and biochemical studies show that natural ribozymes use an impressive range of catalytic mechanisms, beyond metalloenzyme chemistry and analogous to more chemically diverse protein enzymes. These findings make it increasingly possible to compare details of RNA- and protein-based catalysis.

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页码：395 / 402

页数：8

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