Microtermolides A and B from Termite-Associated Streptomyces sp and Structural Revision of Vinylamycin

被引：92

作者：

Carr, Gavin ^{[1
]}

Poulsen, Michael ^{[2
,3
]}

Klassen, Jonathan L. ^{[2
]}

Hou, Yanpeng ^{[4
]}

Wyche, Thomas P. ^{[4
]}

Bugni, Tim S. ^{[4
]}

Currie, Cameron R. ^{[2
]}

Clardy, Jon ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[2] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA

[3] Univ Copenhagen, Inst Biol, Sect Ecol & Evolut, DK-2100 Copenhagen O, Denmark

[4] Univ Wisconsin, Div Pharmaceut Sci, Madison, WI 53706 USA

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 11期

基金：

加拿大自然科学与工程研究理事会;

关键词：

ACIDS;

D O I：

10.1021/ol301043p

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

Microtermolides A (1) and B (2) were isolated from a.Streptomyces sp. strain associated with fungus-growing termites. The structures of 1 and 2 were determined by 1D- and 2D-NMR spectroscopy and high-resolution mass spectrometry. Structural elucidation of 1 led to the re-examination of the structure originally proposed for vinylamycin (3). Based on a comparison of predicted and experimental H-1 and C-13 NMR chemical shifts, we propose that vinylamycin's structure be revised from 3 to 4.

引用

页码：2822 / 2825

页数：4

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