Increasing viscosity of the intestinal contents alters small intestinal structure and intestinal growth, and stimulates proliferation of enterotoxigenic Escherichia coli in newly-weaned pigs

被引:143
作者
McDonald, DE [1 ]
Pethick, DW
Mullan, BP
Hampson, DJ
机构
[1] Murdoch Univ, Div Vet & Biomed Sci, Murdoch, WA 6150, Australia
[2] Agr WA, S Perth, WA, Australia
关键词
intestinal adaptation; viscosity; carboxymethylcellulose; Escherichia coli; pig;
D O I
10.1079/BJN2001416
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Sources of viscous soluble fibre, such as barley and oats, have often been included in the weaning diet of the pig to accelerate development of the large intestine. Inclusion of a non-fermentable, viscous compound, sodium carboxymethylcellulose (CMC), in a low-fibre weaning diet was tested to assess the influence of digesta viscosity on the gut in the absence of increased fermentation. Two CMC sources, of low and high viscosity, were added to cooked rice-based diet at 40 g/kg total diet. A third control rice diet did not contain any CMC. Diets were fed for 13 d following weaning at 3 weeks of age. Addition of CMC to the diet significantly increased the intestinal viscosity of digesta within the small (P <0.001) and large (P <0.05) intestine. No simple association was found between increases in intestinal viscosity and effects on intestinal morphology and whole-body growth. The average empty-body-weight gain and the small intestinal villus height increased with low-viscosity CMC, but decreased with the high-viscosity CMC group. The full large intestinal weight increased in all pigs fed CMC. Dietary CMC (both low- and high-viscosity) increased the percentage moisture of digesta and faeces, and was associated with increased faecal shedding of enterotoxigenic haemolytic Escherichia coli. Feed ingredients in weaning diets that excessively increase the viscosity of the intestinal digesta may be detrimental to pig health and production.
引用
收藏
页码:487 / 498
页数:12
相关论文
共 58 条
[51]   The inhibitory effect of carboxymethylcellulose with high viscosity on lipid absorption in broiler chickens coincides with reduced bile salt concentration and raised microbial numbers in the small intestine [J].
Smits, CHM ;
Veldman, A ;
Verkade, HJ ;
Beynen, AC .
POULTRY SCIENCE, 1998, 77 (10) :1534-1539
[52]   Dietary carboxymethylcellulose with high instead of low viscosity reduces macronutrient digestion in broiler chickens [J].
Smits, CHM ;
Veldman, A ;
Verstegen, MWA ;
Beynen, AC .
JOURNAL OF NUTRITION, 1997, 127 (03) :483-487
[53]   DIETARY MANIPULATION OF GASTRIC PH IN THE PROPHYLAXIS OF ENTERIC DISEASE IN WEANED PIGS - SOME FIELD OBSERVATIONS [J].
THOMLINSON, JR ;
LAWRENCE, TLJ .
VETERINARY RECORD, 1981, 109 (06) :120-122
[54]   THE DEGRADATION OF GUAR GUM BY A FECAL INCUBATION SYSTEM [J].
TOMLIN, J ;
READ, NW ;
EDWARDS, CA ;
DUERDEN, BI .
BRITISH JOURNAL OF NUTRITION, 1986, 55 (03) :481-486
[55]   A VISCOUS FIBER (METHYLCELLULOSE) LOWERS BLOOD-GLUCOSE AND PLASMA TRIACYLGLYCEROLS AND INCREASES LIVER-GLYCOGEN INDEPENDENTLY OF VOLATILE FATTY-ACID PRODUCTION IN THE RAT [J].
TOPPING, DL ;
OAKENFULL, D ;
TRIMBLE, RP ;
ILLMAN, RJ .
BRITISH JOURNAL OF NUTRITION, 1988, 59 (01) :21-30
[56]   EFFECT OF A SOLUBLE POLYSACCHARIDE (CARBOXY METHYL CELLULOSE) ON THE PHYSICOCHEMICAL CONDITIONS IN THE GASTROINTESTINAL-TRACT OF BROILERS [J].
VANDERKLIS, JD ;
VANVOORST, A ;
VANCRUYNINGEN, C .
BRITISH POULTRY SCIENCE, 1993, 34 (05) :971-983
[57]  
Wapnir RA, 1997, P SOC EXP BIOL MED, V215, P275, DOI 10.3181/00379727-215-44139
[58]   INTESTINAL MICROFLORA AND GASTROINTESTINAL ADAPTATION IN THE RAT IN RESPONSE TO NON-DIGESTIBLE DIETARY POLYSACCHARIDES [J].
WYATT, GM ;
HORN, N ;
GEE, JM ;
JOHNSON, IT .
BRITISH JOURNAL OF NUTRITION, 1988, 60 (02) :197-207