Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects

被引：247

作者：

Hirayasu, Y ^{[1
]}

Shenton, ME ^{[1
]}

Salisbury, DF ^{[1
]}

Dickey, CC ^{[1
]}

Fischer, IA ^{[1
]}

Mazzoni, P ^{[1
]}

Kisler, T ^{[1
]}

Arakaki, H ^{[1
]}

Kwon, JS ^{[1
]}

Anderson, JE ^{[1
]}

Yurgelun-Todd, D ^{[1
]}

Tohen, M ^{[1
]}

McCarley, RW ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brockton VA Med Ctr, Dept Psychiat,Clin Neurosci Div,Lab Neurosci, Brockton, MA 02401 USA

来源：

AMERICAN JOURNAL OF PSYCHIATRY | 1998年 / 155卷 / 10期

关键词：

D O I：

10.1176/ajp.155.10.1384

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: Magnetic resonance imaging (MRI) studies of schizophrenic patients have revealed structural brain abnormalities, with low volumes of gray matter in the left posterior superior temporal gyrus and in medial temporal robe structures. However, the specificity to schizophrenia and the roles of chronic morbidity and neuroleptic treatment in these abnormalities remain unclear. Method: Magnetic resonance (1.5-T) scans were obtained from 33 patients with first-episode psychosis and 18 age-matched normal comparison subjects, all right-handed. Sixteen of the patients were diagnosed with affective disorder and 17 with schizophrenia. Results: Quantitative volumetric analysis showed that the patients with first-episode schizophrenia had significantly smaller gray matter volume in the left posterior superior temporal gyrus than did the patients with first-episode affective psychosis or the comparison subjects, with a significant left-less-than-right asymmetry. The schizophrenic patients also showed a smaller gray matter volume of the left posterior amygdala-hippocampal complex than the comparison subjects. Both the patients with schizophrenia and those with affective psychosis had significant left-less-than-right asymmetry of the posterior amygdala-hippocampal complex. Conclusions: These findings suggest that temporal lobe abnormalities are present at the first hospitalization for schizophrenia and that low volume of the left posterior superior temporal gyrus gray matter is specific to schizophrenia compared with affective disorder.

引用

页码：1384 / 1391

页数：8

共 42 条

[11] THE TIMING OF BRAIN MORPHOLOGICAL-CHANGES IN SCHIZOPHRENIA AND THEIR RELATIONSHIP TO CLINICAL OUTCOME [J].