Postbinding functions of CD4 in HIV infection

被引:1
作者
Bachelder, RE [1 ]
Letvin, NL [1 ]
机构
[1] HARVARD UNIV, BETH ISRAEL HOSP,SCH MED,DEPT MED, DIV VIRAL PATHOGENESIS, BOSTON, MA 02215 USA
关键词
D O I
10.1016/0966-842X(96)10043-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Several studies have suggested that the CD4 molecule, in addition to serving as the HIV receptor, may also be involved in postbinding events of HIV infection. The CD4 molecule has been shown to assume an altered conformation on the T-cell surface following HIV binding, which may be involved in these postbinding events.
引用
收藏
页码:359 / 363
页数:5
相关论文
共 48 条
  • [21] NOVEL ANTI-CD4 MONOCLONAL-ANTIBODIES SEPARATE HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION AND FUSION OF CD4+ CELLS FROM VIRUS BINDING
    HEALEY, D
    DIANDA, L
    MOORE, JP
    MCDOUGAL, JS
    MOORE, MJ
    ESTESS, P
    BUCK, D
    KWONG, PD
    BEVERLEY, PCL
    SATTENTAU, QJ
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (04) : 1233 - 1242
  • [22] HUMAN-IMMUNODEFICIENCY-VIRUS GP120 AND DERIVED PEPTIDES ACTIVATE PROTEIN TYROSINE KINASE P56LCK IN HUMAN CD4 T-LYMPHOCYTES
    HIVROZ, C
    MAZEROLLES, F
    SOULA, M
    FAGARD, R
    GRATON, S
    MELOCHE, S
    SEKALY, RP
    FISCHER, A
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (03) : 600 - 607
  • [23] HIV-1 GLYCOPROTEIN GP120 DISRUPTS CD4-P56(LCK)/CD3-T CELL-RECEPTOR INTERACTIONS AND INHIBITS CD3 SIGNALING
    HUBERT, P
    BISMUTH, G
    KORNER, M
    DEBRE, P
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (05) : 1417 - 1425
  • [24] THE ROLE OF CD4 IN T-CELL ACTIVATION - ACCESSORY MOLECULE OR CO-RECEPTOR
    JANEWAY, CA
    [J]. IMMUNOLOGY TODAY, 1989, 10 (07): : 234 - 238
  • [25] JUSZCZAK RJ, 1991, J BIOL CHEM, V266, P11176
  • [26] KANNER SB, 1995, J IMMUNOL, V154, P2996
  • [27] KEATING MT, 1988, J BIOL CHEM, V263, P12805
  • [28] A MONOCLONAL-ANTIBODY TO THE GP120-CD4 COMPLEX HAS DIFFERENTIAL-EFFECTS ON HIV-INDUCED SYNCYTIUM FORMATION AND VIRAL INFECTIVITY
    KONOPKA, K
    PRETZER, E
    CELADA, F
    DUZGUNES, N
    [J]. JOURNAL OF GENERAL VIROLOGY, 1995, 76 : 669 - 679
  • [29] MOLECULAR CHARACTERISTICS OF RECOMBINANT HUMAN CD4 AS DEDUCED FROM POLYMORPHIC CRYSTALS
    KWONG, PD
    RYU, SE
    HENDRICKSON, WA
    AXEL, R
    SWEET, RM
    FOLENAWASSERMAN, G
    HENSLEY, P
    SWEET, RW
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (16) : 6423 - 6427
  • [30] LANGEDIJK JPM, 1993, J BIOL CHEM, V268, P16875