(R)-3-(N-methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity h5-HT1B/1D ligands

被引：5

作者：

Egle, I ^{[1
]}

MacLean, N ^{[1
]}

Demchyshyn, L ^{[1
]}

Edwards, L ^{[1
]}

Slassi, A ^{[1
]}

Tehim, A ^{[1
]}

机构：

[1] NPS Pharmaceut Inc, Mississauga, ON L4V 1V7, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(03)00779-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of (R)- 3-(N-methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives (2) have been prepared using parallel synthesis, and their structure-activity relationship studied. High affinity human 5-HT1B/1D (h5-HT1B/1D) ligands have been identified. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3419 / 3421

页数：3

共 16 条

[11] 5-[(3-NITROPYRID-2-YL)AMINO]INDOLES - NOVEL SEROTONIN AGONISTS WITH SELECTIVITY FOR THE 5-HT1D RECEPTOR - VARIATION OF THE C3 SUBSTITUENT ON THE INDOLE TEMPLATE LEADS TO INCREASED 5-HT1D RECEPTOR SELECTIVITY [J].