The role of bacterial biofilm in persistent infections and control strategies

被引:170
作者
Chen, Li [1 ]
Wen, Yu-mei
机构
[1] Fudan Univ, Key Lab Med Mol Virol, Minist Educ, Shanghai 200032, Peoples R China
关键词
biofilm; persistent infection; 3A remedies; STAPHYLOCOCCUS-AUREUS BIOFILM; PSEUDOMONAS-AERUGINOSA; STREPTOCOCCUS-MUTANS; SORTASE; IDENTIFICATION; PROTECTION; VIRULENCE; PROTEINS; THERAPY; PEPTIDE;
D O I
10.4248/IJOS11022
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Bacterial biofilms can be viewed as a specific type of persistent bacterial infection. After initial invasion, microbes can attach to living and non-living surfaces, such as prosthetics and indwelling medical devices, and form a biofilm composed of extracellular polysaccharides, proteins, and other components. In hosts, biofilm formation may trigger drug resistance and inflammation, resulting in persistent infections. The clinical aspects of biofilm formation and leading strategies for biofilm inhibitors will be discussed in this mini-review.
引用
收藏
页码:66 / 73
页数:8
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