Endothelial progenitor cells: a new target for the prevention of cardiovascular diseases

被引：16

作者：

Brixius, Klara

Funcke, Fabienne

Graf, Christine ^{[2
]}

Bloch, Wilhelm ^{[1
]}

机构：

[1] German Sport Univ Cologne, Inst Cardiol & Sport Med, Dept Mol & Cellular Sport Med, D-50933 Cologne, Germany

[2] German Sport Univ Cologne, Dept Cardiol & Sport Med, D-50933 Cologne, Germany

来源：

EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION | 2006年 / 13卷 / 05期

关键词：

coronary artery disease; endothelial progenitor cells; exercise; review; stem cell therapy;

D O I：

10.1097/01.hjr.0000221862.34662.31

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Endothelial progenitor cells (EPCs) are circulating precursor cells that have been implicated recently in vascular and cardiac regeneration. There is an ongoing discussion on the immunocytological definition of EPCs, based on various surface markers, and currently different cell types are included in the term 'EPC'. This review summarizes the mechanisms that influence function, survival, mobilization and differentiation of EPCs. Furthermore, there are several reports on the clinical use of EPCs for the treatment of cardiovascular diseases. We have focused specifically on the influence of physical activity on EPC function. Eur J Cardiovasc Prev Rehabil 13:705-710 (C) 2006 The European Society of Cardiology

引用

页码：705 / 710

页数：6

共 75 条

[1] Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia [J].

Adams, V ;

Lenk, K ;

Linke, A ;

Lenz, D ;

Erbs, S ;

Sandri, M ;

Tarnok, A ;

Gielen, S ;

Emmrich, F ;

Schuler, G ;

Hambrecht, R .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (04) :684-690

[2] Mobilizing endothelial progenitor cells [J].

Aicher, A ;

Zeiher, AM ;

Dimmeler, S .

HYPERTENSION, 2005, 45 (03) :321-325

[3] ERYTHROPOIETIN HAS A MITOGENIC AND POSITIVE CHEMOTACTIC EFFECT ON ENDOTHELIAL-CELLS [J].

ANAGNOSTOU, A ;

LEE, ES ;

KESSIMIAN, N ;

LEVINSON, R ;

STEINER, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (15) :5978-5982

[4] ERYTHROPOIETIN RECEPTOR MESSENGER-RNA EXPRESSION IN HUMAN ENDOTHELIAL-CELLS [J].

ANAGNOSTOU, A ;

LIU, ZY ;

STEINER, M ;

CHIN, K ;

LEE, ES ;

KESSIMIAN, N ;

NOGUCHI, CT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :3974-3978

[5] Isolation of putative progenitor endothelial cells for angiogenesis [J].

Asahara, T ;

Murohara, T ;

Sullivan, A ;

Silver, M ;

vanderZee, R ;

Li, T ;

Witzenbichler, B ;

Schatteman, G ;

Isner, JM .

SCIENCE, 1997, 275 (5302) :964-967

[6] Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization [J].

Asahara, T ;

Masuda, H ;

Takahashi, T ;

Kalka, C ;

Pastore, C ;

Silver, M ;

Kearne, M ;

Magner, M ;

Isner, JM .

CIRCULATION RESEARCH, 1999, 85 (03) :221-228

[7] VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells [J].

Asahara, T ;

Takahashi, T ;

Masuda, H ;

Kalka, C ;

Chen, DH ;

Iwaguro, H ;

Inai, Y ;

Silver, M ;

Isner, JM .

EMBO JOURNAL, 1999, 18 (14) :3964-3972

[8] Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy [J].

Askari, AT ;

Unzek, S ;

Popovic, ZB ;

Goldman, CK ;

Forudi, F ;

Kiedrowski, M ;

Rovner, A ;

Ellis, SG ;

Thomas, JD ;

DiCorleto, PE ;

Topol, EJ ;

Penn, MS .

LANCET, 2003, 362 (9385) :697-703

[9] Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction -: (TOPCARE-AMI) [J].

Assmus, B ;

Schächinger, V ;

Teupe, C ;

Britten, M ;

Lehmann, R ;

Döbert, N ;

Grünwald, F ;

Aicher, A ;

Urbich, C ;

Martin, H ;

Hoelzer, D ;

Dimmeler, S ;

Zeiher, AM .

CIRCULATION, 2002, 106 (24) :3009-3017

[10] Stimulation of endothelial progenitor cells - A new putative therapeutic effect of angiotensin II receptor antagonists [J].

Bahlmann, FH ;

de Groot, K ;

Mueller, O ;

Hertel, B ;

Haller, H ;

Fliser, D .

HYPERTENSION, 2005, 45 (04) :526-529

← 1 2 3 4 5 6 7 8 →