Two novel reassortants of avian influenza A (H5N6) virus in China

被引：85

作者：

Bi, Yuhai ^{[1
,2
]}

Mei, Kun ^{[3
,4
]}

Shi, Weifeng ^{[5
]}

Liu, Di ^{[1
,2
]}

Yu, Xiaolan ^{[4
]}

Gao, Zhimin ^{[3
]}

Zhao, Lihua ^{[3
]}

Gao, George F. ^{[1
,2
,3
,6
,7
]}

Chen, Jianjun ^{[2
,3
]}

Chen, Quanjiao ^{[2
,3
]}

机构：

[1] Chinese Acad Sci, CAS Key Lab Pathogen Microbiol & Immunol CASPMI, Inst Microbiol, Beijing 100101, Peoples R China

[2] Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, Beijing 100101, Peoples R China

[3] Chinese Acad Sci, CAS Key Lab Special Pathogens & Biosafety, Wuhan Inst Virol, Wuhan 430071, Hubei, Peoples R China

[4] Hubei Univ, Wuhan 430062, Hubei, Peoples R China

[5] Taishan Med Coll, Inst Pathogen Biol, Shandong 271016, Peoples R China

[6] Chinese Ctr Dis Control & Prevent China CDC, Off Director Gen, Beijing 102206, Peoples R China

[7] Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China

来源：

JOURNAL OF GENERAL VIROLOGY | 2015年 / 96卷

基金：

中国国家自然科学基金;

关键词：

MIGRATORY BIRDS; DOMESTIC DUCKS; HONG-KONG; HEMAGGLUTININ; INFECTION; PATHOGENESIS; EVOLUTION; VIRULENCE; OUTBREAKS; VARIANTS;

D O I：

10.1099/vir.0.000056

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Eight avian influenza A (H5N6) viruses were isolated from live poultry markets (LPMs) in Sichuan and Jiangxi Provinces in China in 2014, including those close to the county where the human H5N6 infection occurred. Genetic and phylogenetic analyses revealed that these H5N6 viruses were novel reassortants between H5N1 clade 2.3.4 and H6N6 viruses, and had evolved into two distinct lineages (Sichuan and Jiangxi). Moreover, the human H5N6 virus was closely related to the avian-source viruses of Sichuan lineage. Notably, H5N6 viruses contained a T160A substitution in the haemagglutinin protein and an 11 aa deletion in the neuraminidase stalk, which may aid in enhancing viral affinity for human-like receptors and virulence in mammals. As the H5N1 virus infects humans through direct contact, infection with the novel H5N6 virus raised significant concerns that the H5 subtype was a likely candidate for a pandemic. Therefore, extensive and long-term surveillance of avian influenza viruses in LPMs is essential.

引用

页码：975 / 981

页数：7

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