Highly selective 1,3-dipolar cycloaddition of a cyclic azomethine ylide to ethyltrifluorocrotonates

被引：15

作者：

Bégué, JP ^{[1
]}

Bonnet-Delpon, D ^{[1
]}

Chennoufi, A ^{[1
]}

Ourévitch, M ^{[1
]}

Ravikumar, KS ^{[1
]}

Rock, MH ^{[1
]}

机构：

[1] Ctr Etud Pharmaceut, CNRS, BioCIS, F-92296 Chatenay Malabry, France

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2001年 / 107卷 / 02期

关键词：

1,3-dipolar cycloaddition; pyrrolidine; azomethine ylide; aspartate; trifluoromethyl compounds;

D O I：

10.1016/S0022-1139(00)00370-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The 1,3-dipolar cycloadditions of ethyltrifluorocrotonates to the azomethineylide, generated from 2-(tert-butyl)-3-methyl-imidazolin-4-one and formaldehyde, proceeds with a high degree of stereo- and regioselectivity to give precursors of 4-trifluoromethylpyrrolidine-2,3-dicarboxylic acids in good yields. (C) 2001 Elsevier Science B.V. Air rights reserved.

引用

页码：275 / 279

页数：5

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