Rhizomucor miehei lipase as the catalyst in the resolution of chiral compounds:: an overview

被引：30

作者：

Alcantara, AR ^{[1
]}

de Fuentes, IE ^{[1
]}

Sinisterra, JV ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Pharm, Dept Organ & Pharmaceut Chem, E-28040 Madrid, Spain

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1998年 / 93卷 / 1-2期

关键词：

Rhizomucor miehei; lipase; resolution; chiral compounds;

D O I：

10.1016/S0009-3084(98)00041-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rhizomucor miehei lipase is probably the most used lipase obtained from fungi, even being used as a model for the determination of the structure of some other lipases due to the deep knowledge of its three dimensional structure. In this paper we present an overview of the use of this lipase for the obtention of homochiral compounds via hydrolytic and acyl transfer methodologies. The application for the resolution of both chiral carboxylic acids and alcohol is also presented. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：169 / 184

页数：16

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