Directional modifications of resibufogenin by Mucor subtilissimus and Pseudomonas aeruginosa

被引：12

作者：

Zhan, JX

Zhang, YX

Liu, WH

Guo, HZ

Guo, D ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

[2] E China Univ Sci & Technol, Lab Bioreactor Engn, Shanghai 200237, Peoples R China

来源：

BIOCATALYSIS AND BIOTRANSFORMATION | 2003年 / 21卷 / 03期

基金：

中国国家自然科学基金;

关键词：

directional modifications; resibufogenin; hydroxylation; Mucor subtilissimus; dehydrogenation; Pseudomonas aeruginosa;

D O I：

10.1080/10242420310001597793

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Directional modifications of resibufogenin 1 by Mucor subtilissimus and Pseudomonas aeruginosa were carried out. The substrate was hydroxylated at C-12 by M . subtilissimus AS 3.2454, from which a major product 12-hydroxyresibufogenin 2 was obtained. Then product 2 was dehydrogenated by P . aeruginosa AS 1.860, which resulted in a new compound 12beta-hydroxy-3-keto-resibufogenin 3.

引用

页码：141 / 143

页数：3

共 10 条

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