Insights into the regulation of transcription by scanning force microscopy

被引：17

作者：

Dame, RT

Wyman, C

Goosen, N

机构：

[1] Free Univ Amsterdam, Dept Phys & Astron, NL-1081 HV Amsterdam, Netherlands

[2] Erasmus MC, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

[3] Erasmus MC, Dept Radiat Oncol, NL-3000 DR Rotterdam, Netherlands

[4] Leiden Univ, Leiden Inst Chem, Gorlaeus Labs, Mol Genet Lab, NL-2300 RA Leiden, Netherlands

来源：

JOURNAL OF MICROSCOPY-OXFORD | 2003年 / 212卷 / 03期

关键词：

AFM; atomic force microscopy; DNA; RNA polymerase; scanning force microscopy; SFM; transcription;

D O I：

10.1111/j.1365-2818.2003.01243.x

中图分类号：

TH742 [显微镜];

学科分类号：

摘要：

The scanning force microscope (SFM) is a valuable tool for the structural analysis of complexes between protein(s) and DNA. In recent years the application of scanning force microscopy to the field of transcription regulation has been reported in numerous studies. Using this technique, novel insights could be obtained into the architecture and dynamics of complexes, which are relevant to the transcription process and the mechanisms by which this process is regulated. In this article an overview is given of SFM studies addressing, in particular, topics in the field of transcription in prokaryotic organisms.

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收藏

页码：244 / 253

页数：10

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