Safeguarding parental identity: Dnmt1 maintains imprints during epigenetic reprogramming in early embryogenesis

被引：57

作者：

Branco, Miguel R. ^{[1
]}

Oda, Masaaki ^{[1
]}

Reik, Wolf ^{[1
]}

机构：

[1] Babraham Inst, Lab Dev Genet & Imprinting, Cambridge CB22 3AT, England

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 12期

基金：

英国医学研究理事会;

关键词：

genomic imprinting; DNA methylation; pre-implantation embryos; Dnmt1;

D O I：

10.1101/gad.1690508

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During early mammalian embryogenesis, the genome undergoes global epigenetic reprogramming, losing most of its methylation before re-establishing it de novo at implantation. However, faithful maintenance of methylation at imprinted genes during this process is vital for embryonic development, but the DNA methyltransferase responsible for this maintenance has remained unknown. In this issue of Genes & Development, Hirasawa and colleagues (pp. 1607-1616) show that Dnmt1, and not Dnmt3a or Dnmt3b, maintains methylation at genomic imprints during preimplantation development.

引用

页码：1567 / 1571

页数：5

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