Resveratrol as a Novel Anti-Herpes Simplex Virus Nutraceutical Agent: An Overview

被引：75

作者：

Annunziata, Giuseppe ^{[1
]}

Maisto, Maria ^{[1
]}

Schisano, Connie ^{[1
]}

Ciampaglia, Roberto ^{[1
]}

Narciso, Viviana ^{[1
]}

Tenore, Gian Carlo ^{[1
]}

Novellino, Ettore ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy

来源：

VIRUSES-BASEL | 2018年 / 10卷 / 09期

关键词：

herpes simplex virus; HSV-1; HSV-2; resveratrol; polyphenols; nutraceutical; NF-KAPPA-B; AMPK/SIRT1; AXIS; HSV-1; INFECTION; IN-VIVO; ACTIVATION; APOPTOSIS; CELLS; MECHANISM; DNA; INFLAMMATION;

D O I：

10.3390/v10090473

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

The herpes simplex virus (HSV) is a common human virus affecting many people worldwide. HSV infections manifest with lesions that occur in different parts of the body, including oral, ocular, nasal, and genital skin and mucosa. In rare cases, HSV infections can be serious and lethal. Several anti-HSV drugs have been developed, but the existence of mutant viruses resistant to these drugs led to the individuation of novel antiviral agents. Plant-derived bioactive compounds, and more specifically polyphenols, have been demonstrated to exert marked anti-HSV activity and, among these, resveratrol (RSV) would be considered a good candidate. The purpose of this manuscript is to review the available literature elucidating the efficacy of RSV against HSV and the main demonstrated mechanisms of action.

引用

收藏

页数：10

相关论文

共 48 条

[1]

Biological activity of resveratrol, a stilbenic compound from grapevines, against Botrytis cinerea, the causal agent for gray mold [J].

Adrian, M ;

Jeandet, P ;

Veneau, J ;

Weston, LA ;

Bessis, R .

JOURNAL OF CHEMICAL ECOLOGY, 1997, 23 (07) :1689-1702

[2]

Herpes simplex virus disrupts NF-κB regulation by blocking its recruitment on the IκBα promoter and directing the factor on viral genes [J].

Amici, C ;

Rossi, A ;

Costanzo, A ;

Ciafrè, S ;

Marinari, B ;

Balsamo, M ;

Levrero, M ;

Santoro, MG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (11) :7110-7117

[3]

Therapeutic potential of resveratrol:: the in vivo evidence [J].

Baur, Joseph A. ;

Sinclair, David A. .

NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (06) :493-506

[4]

Resveratrol exhibits a strong cytotoxic activity in cultured cells and has an antiviral action against polyomavirus: potential clinical use [J].

Berardi, Valerio ;

Ricci, Francesca ;

Castelli, Mauro ;

Galati, Gaspare ;

Risuleo, Gianfranco .

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2009, 28

[5]

Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-κB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells [J].

Bhardwaj, Anjana ;

Sethi, Gautam ;

Vadhan-Raj, Saroj ;

Bueso-Ramos, Carlos ;

Takada, Yasunari ;

Gaur, Upasna ;

Nair, Asha S. ;

Shishodia, Shishir ;

Aggarwal, Bharat B. .

BLOOD, 2007, 109 (06) :2293-2302

[6]

Comprehensive review on the antimicrobial potency of the plant polyphenol Resveratrol [J].

Bostanghadiri, Narjess ;

Pormohammad, Ali ;

Chirani, Alireza Salimi ;

Pouriran, Ramin ;

Erfanimanesh, Soroor ;

Hashemi, Ali .

BIOMEDICINE & PHARMACOTHERAPY, 2017, 95 :1588-1595

[7]

Resveratrol: French paradox revisited [J].

Catalgol, Betul ;

Batirel, Saime ;

Taga, Yavuz ;

Ozer, Nesrin Kartal .

FRONTIERS IN PHARMACOLOGY, 2012, 3

[8]

Potent Inhibition of HIV-1 Replication in Resting CD4 T Cells by Resveratrol and Pterostilbene [J].

Chan, Chi N. ;

Trinite, Benjamin ;

Levy, David N. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2017, 61 (09)

[9]

Inhibition of herpes simplex virus infection by oligomeric stilbenoids through ROS generation [J].

Chen, Xiaoqing ;

Qiao, Haishi ;

Liu, Taixiang ;

Yang, Ziying ;

Xu, Lanfang ;

Xu, Yunxia ;

Ge, Hui Ming ;

Tan, Ren-Xiang ;

Li, Erguang .

ANTIVIRAL RESEARCH, 2012, 95 (01) :30-36

[10]

Cutting edge: Apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by. lipopolysaccharide [J].

Chiang, Edward ;

Dang, Oanh ;

Anderson, Keith ;

Matsuzawa, Atsushi ;

Ichijo, Hidenori ;

David, Michael .

JOURNAL OF IMMUNOLOGY, 2006, 176 (10) :5720-5724

← 1 2 3 4 5 →