An unexpected role for ubiquitylation of a transcriptional activator

被引：3

作者：

Arndt, K ^{[1
]}

Winston, F

机构：

[1] Univ Pittsburgh, Dept Biol Sci, Pittsburgh, PA 15260 USA

[2] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

来源：

CELL | 2005年 / 120卷 / 06期

关键词：

D O I：

10.1016/j.cell.2005.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The yeast transcriptional activator Gal4 has served as a paradigm for understanding how eukaryotic cells mount rapid transcriptional responses to environmental changes. In this issue of Cell, Muratani et al. (2005) provide evidence that Gal4 ubiquitylation and destruction are required for activation by Gal4. Surprisingly, this modification is required at a postinitiation step in transcription for the production of mRNAs that are correctly processed and fully functional for translation.

引用

页码：733 / 734

页数：2

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