Lucentamycins A-D, cytotoxic peptides from the marine-derived actinomycete Nocardiopsis lucentensis

被引：88

作者：

Cho, Ji Young ^{[1
]}

Williams, Philip G. ^{[1
]}

Kwon, Hak Chol ^{[1
]}

Jensen, Paul R. ^{[1
]}

Fenical, William ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 08期

关键词：

D O I：

10.1021/np070101b

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new 3-methyl-4-ethylideneproline-containing peptides, lucentamycins A-D (1-4), have been isolated from the fermentation broth of a marine-derived actinomycete identified by phylogenetic methods as Nocardiopsis lucentensis (strain CNR-712). The planar structures of the new compounds were assigned on the basis of 1D and 2D NMR spectroscopic techniques, while the absolute configurations of the amino acid residues were determined by application of the advanced Marfey method. Lucentamycins A (1) and B (2) showed significant in vitro cytotoxicity against HCT-116 human colon carcinoma.

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页码：1321 / 1328

页数：8

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