Intracellular enzymatic formation of nanofibers results in hydrogelation and regulated cell death

被引：260

作者：

Yang, Zhimou

Xu, Keming

Guo, Zufeng

Guo, Zhihong

Xu, Bing ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Univ Sci & Technol, Bioengn Program, Hong Kong, Hong Kong, Peoples R China

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 20期

关键词：

D O I：

10.1002/adma.200701971

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enzymatic formation of supramolecular nanofibers is demonstrated as a novel approach to induce intracellular hydrogelation and control the fate of cells or cellular functions, which can lead to a new paradigm for developing biomaterials to manage cellular artificial nanostructures (CAN), understand cellular functions beyond the molecular level, and create novel therapeutics.

引用

收藏

页码：3152 / +

页数：6

相关论文

共 52 条

[1] An insulin-sensing sugar-based fluorescent hydrogel [J].

Bhuniya, S ;

Kim, BH .

CHEMICAL COMMUNICATIONS, 2006, (17) :1842-1844

[2] (S)-(+)-Ibuprofen-based hydrogelators:: an approach toward anti-inflammatory drug delivery [J].

Bhuniya, Sankarprasad ;

Seo, Young Jun ;

Kim, Byeang Hyean .

TETRAHEDRON LETTERS, 2006, 47 (40) :7153-7156

[3] Surface-induced hydrogelation [J].

Bieser, AM ;

Tiller, JC .

CHEMICAL COMMUNICATIONS, 2005, (31) :3942-3944

[4] Geometric control of cell life and death [J].

Chen, CS ;

Mrksich, M ;

Huang, S ;

Whitesides, GM ;

Ingber, DE .

SCIENCE, 1997, 276 (5317) :1425-1428

[5]

Estroff LA, 2000, ANGEW CHEM INT EDIT, V39, P3447, DOI 10.1002/1521-3773(20001002)39:19<3447::AID-ANIE3447>3.0.CO

[6]

2-X

[7] Water gelation by small organic molecules [J].

Estroff, LA ;

Hamilton, AD .

CHEMICAL REVIEWS, 2004, 104 (03) :1201-1217

[8] Charge transport through self-assembled monolayers of compounds of interest in molecular electronics [J].

Fan, FRF ;

Yang, JP ;

Cai, LT ;

Price, DW ;

Dirk, SM ;

Kosynkin, DV ;

Yao, YX ;

Rawlett, AM ;

Tour, JM ;

Bard, AJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (19) :5550-5560

[9] Using biofunctional magnetic nanoparticles to capture vancomycin-resistant enterococci and other gram-positive bacteria at ultralow concentration [J].

Gu, HW ;

Ho, PL ;

Tsang, KWT ;

Wang, L ;

Xu, B .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (51) :15702-15703

[10] Patterned Langmuir-Blodgett films of mondisperse nanoparticles of iron oxide using soft lithography [J].

Guo, QJ ;

Teng, XW ;

Rahman, S ;

Yang, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (03) :630-631

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