IMPACT: Integrated Multiprogram Platform for Analyses in ConTest

被引：2

作者：

Maldonado, Emanuel ^{[1
,2
]}

Dutheil, Julien Y. ^{[3
]}

Da Fonseca, Rute R. ^{[1
]}

Vasconcelos, Vitor ^{[1
,4
]}

Antunes, Agostinho ^{[1
]}

机构：

[1] Univ Porto, Ctr Interdisciplinar Invest Marinha & Ambiental, CIMAR CIIMAR, P-4050123 Oporto, Portugal

[2] Univ Porto, Dept Ciencia Comp, Fac Ciencias, P-4050123 Oporto, Portugal

[3] Univ Montpellier 2, Inst Sci Evolut Montpellier, Montpellier, France

[4] Univ Porto, Fac Ciencias, Dept Biol, Oporto, Portugal

来源：

JOURNAL OF HEREDITY | 2011年 / 102卷 / 03期

关键词：

evolutionary bioinformatics; functional genomics; molecular adaptation and selection; protein evolution; EVOLUTION;

D O I：

10.1093/jhered/esr003

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this paper, we introduce a new Graphical User Interface that estimates evolutionary rates on protein sequences by assessing changes in biochemical constraints. We describe IMPACT, a platform-independent (tested in Linux, Windows, and MacOS) easy to install software written in Java. IMPACT integrates the use of a built-in multiple sequence alignment editor, with programs that perform phylogenetic and protein structure analyses (ConTest, PhyML, ATV, and Jmol) allowing the user to quickly and efficiently perform evolutionary analyses on protein sequences, including the detection of selection (negative and positive) signatures at the amino acid scale, which can provide fundamental insight about species evolution and ecological fitness. IMPACT provides the user with a working platform that combines a number of bioinformatics tools and utilities in one place, transferring information directly among the various programs and therefore increasing the overall performance of evolutionary analyses on proteins.

引用

页码：366 / 369

页数：4

共 11 条

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