Angiogenesis in fracture repair

被引:309
作者
Glowacki, J
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Orthoped Surg,Skeletal Biol Lab, Boston, MA 02115 USA
[2] Harvard Univ, Massachusetts Gen Hosp, Sch Dent Med, Skeletal Biol Res Ctr, Boston, MA 02115 USA
关键词
D O I
10.1097/00003086-199810001-00010
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Fracture of bone disrupts its circulation and leads to necrosis and hypoxia of adjacent bone. Under normal circumstances, fractured bone undergoes the orderly regeneration of its component tissues with complete restoration of mechanical properties. Reestablishment of the circulation is an early event in fracture healing. Several experimental models of protracted, impaired, or compromised healing have been developed to evaluate the effects of angiogenic factors in accelerating or enhancing repair.
引用
收藏
页码:S82 / S89
页数:8
相关论文
共 60 条
[21]  
GLOWACKI J, 1986, J ARTHROSCOPIC REL S, V2, P169
[22]   Enhanced expression of vascular endothelial growth factor in human SaOS-2 osteoblast-like cells and murine osteoblasts induced by insulin-like growth factor I [J].
Goad, DL ;
Rubin, J ;
Wang, H ;
Tashjian, AH ;
Patterson, C .
ENDOCRINOLOGY, 1996, 137 (06) :2262-2268
[23]   INHIBITION OF TUMOR-GROWTH, VASCULARIZATION, AND COLLAGENOLYSIS IN THE RABBIT CORNEA BY MEDROXYPROGESTERONE [J].
GROSS, J ;
AZIZKHAN, RG ;
BISWAS, C ;
BRUNS, RR ;
HSIEH, DST ;
FOLKMAN, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (02) :1176-1180
[24]  
HARADA S, 1995, CLIN ORTHOP RELAT R, P76
[25]  
HEPPENSTALL RB, 1975, CLIN ORTHOP RELAT R, P357
[26]   A STANDARDIZED EXPERIMENTAL FRACTURE IN THE MOUSE TIBIA [J].
HILTUNEN, A ;
VUORIO, E ;
ARO, HT .
JOURNAL OF ORTHOPAEDIC RESEARCH, 1993, 11 (02) :305-312
[27]  
Hunter John., 1794, A Treatise on the Blood, Inflammation, and Gun-shot Wounds
[28]  
KELLY PJ, 1990, CLIN ORTHOP RELAT R, P275
[29]  
KIRCHEN ME, 1995, CLIN ORTHOP RELAT R, V318, P231
[30]  
KLAGSBRUN M, 1995, MOL CARDIOVASCULAR M, P63