Female Reproductive Factors, Gene Polymorphisms in the Estrogen Metabolism Pathway, and Risk of Lung Cancer in Chinese Women

被引:38
作者
Lim, Wei-Yen [1 ]
Chen, Ying [1 ]
Chuah, Khoon Leong [2 ]
Eng, Philip [3 ]
Leong, Swan Swan [4 ]
Lim, Elaine [5 ]
Lim, Tow Keang [6 ]
Ng, Alan [5 ]
Poh, Wee Teng [7 ]
Tee, Augustine [8 ]
Teh, Ming [2 ]
Salim, Agus [1 ]
Seow, Adeline [1 ]
机构
[1] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117597, Singapore
[2] Tan Tock Seng Hosp, Dept Pathol, Singapore, Singapore
[3] Mt Elizabeth Hosp, Singapore, Singapore
[4] Natl Canc Ctr, Dept Med Oncol, Singapore, Singapore
[5] Tan Tock Seng Hosp, Dept Resp & Crit Care Med, Singapore, Singapore
[6] Natl Univ Singapore Hosp, Dept Med, Singapore, Singapore
[7] Changi Gen Hosp, Dept Lab Med, Singapore, Singapore
[8] Changi Gen Hosp, Div Resp Med, Singapore, Singapore
基金
英国医学研究理事会;
关键词
estrogen; etiology; lung neoplasms; reproductive history; HORMONE REPLACEMENT THERAPY; NEVER SMOKERS; POSTMENOPAUSAL WOMEN; RECEPTOR-BETA; SMOKING; ADENOCARCINOMA; ASSOCIATION; SINGAPORE; TOBACCO; HEALTH;
D O I
10.1093/aje/kwr332
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The authors examined relations between reproductive factors and 5 estrogen pathway gene polymorphisms (CYP17 rs743572, CYP19A1 rs10046, ER beta rs1256049, ER beta rs4986938, and COMT rs4680) among 702 Singapore Chinese female lung cancer cases and 1,578 hospital controls, of whom 433 cases (61.7%) and 1,375 controls (87.1%) were never smokers. Parity (per child, odds ratio (OR) = 0.92, 95% confidence interval (CI): 0.87, 0.97) and menstrual cycle length (for >= 30 days vs. < 30 days, OR = 0.50, 95% CI: 0.32, 0.80) were inversely associated with lung cancer in never smokers, while age at first birth (for ages 21-25, 26-30, and >= 31 years vs. < 20 years, ORs were 1.54, 2.17, and 1.30, respectively), age at menopause (for ages 49-51 and >= 52 years vs. < 48 years, ORs were 1.37 and 1.59; P-trend = 0.003), and reproductive period (for 31-33, 34-36, 37-39, and >= 40 years vs. < 30 years, ORs were 1.06, 1.25, 1.45, and 1.47; P-trend = 0.026) were positively associated. Among smokers, parity was inversely associated with lung cancer, but there was no association with other reproductive factors. The COMT rs4680 A allele was positively associated with lung cancer in never smokers (for G/A or A/A vs. G/G, OR = 1.46, 95% CI: 1.12, 1.90) but not in ever smokers. No associations were seen with other polymorphisms. These results support a risk-enhancing role of estrogens in lung carcinogenesis among never smokers.
引用
收藏
页码:492 / 503
页数:12
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