Lung Cancer and Hormone Replacement Therapy: Association in the Vitamins and Lifestyle Study

被引:124
作者
Slatore, Christopher G. [1 ]
Chien, Jason W.
Au, David H.
Satia, Jessie A.
White, Emily
机构
[1] Portland VA Med Ctr, Portland, OR 97239 USA
基金
美国国家卫生研究院;
关键词
FOOD FREQUENCY QUESTIONNAIRE; GROWTH-FACTOR RECEPTOR; ESTROGEN-RECEPTOR; REPRODUCTIVE FACTORS; BETA-CAROTENE; WOMEN; RISK; SMOKING; COHORT; EPIDEMIOLOGY;
D O I
10.1200/JCO.2009.25.9739
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose Lung cancer is the leading cause of cancer-related mortality among women. The role of hormone replacement therapy (HRT) in lung cancer development is unclear. Patients and Methods We evaluated a prospective cohort of 36,588 peri-and postmenopausal women aged 50 to 76 years from Washington State recruited in 2000 to 2002 (Vitamins and Lifestyle [VITAL] Study). Lung cancer cases (n = 344) were identified through the Seattle-Puget Sound Surveillance, Epidemiology, and End Results cancer registry during 6 years of follow-up. Hazard ratios (HRs) associated with use and duration of specific HRT formulations were calculated for total incident lung cancer, specific morphologies, and cancer by stage at diagnosis. Results After adjusting for smoking, age, and other potential confounders, there was an increased risk of incident lung cancer associated with increasing duration of estrogen plus progestin (E + P) use (HR = 1.27 for E + P use 1 to 9 years, 95% CI, 0.91 to 1.78; and HR = 1.48 for E + P use >= 10 years, 95% CI, 1.03 to 2.12; P for trend = . 03). There was no association with duration of unopposed estrogen use. Duration of E + P use was associated with an advanced stage at diagnosis (P for trend = .03). Conclusion Use of E + P increased the risk of incident lung cancer in a duration-dependent manner, with an approximate 50% increased risk for use of 10 years or longer. These findings may be helpful for informing women of their risk of developing lung cancer and delineating important pathways involved in hormone metabolism and lung cancer.
引用
收藏
页码:1540 / 1546
页数:7
相关论文
共 50 条
[1]   RISK OF CANCER IN WOMEN RECEIVING HORMONE REPLACEMENT THERAPY [J].
ADAMI, HO ;
PERSSON, I ;
HOOVER, R ;
SCHAIRER, C ;
BERGKVIST, L .
INTERNATIONAL JOURNAL OF CANCER, 1989, 44 (05) :833-839
[2]  
[Anonymous], N ENGL J MED
[3]  
[Anonymous], 2006, SEER cancer statistics review, 1975-2003
[4]  
[Anonymous], 2004, HLTH CONSEQUENCES SM
[5]   Women and lung cancer: Epidemiology, tumor biology, and emerging trends in clinical research [J].
Belani, Chandra P. ;
Marts, Sherry ;
Schiller, Joan ;
Socinski, Mark A. .
LUNG CANCER, 2007, 55 (01) :15-23
[6]   Estrogen replacement therapy and risk of lung cancer [J].
Blackman, JA ;
Coogan, PF ;
Rosenberg, L ;
Strom, BL ;
Zauber, AG ;
Palmer, JR ;
Langenberg, P ;
Shapiro, S .
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2002, 11 (07) :561-567
[7]   Estrogen and Its Receptors in Cancer [J].
Chen, George G. ;
Zeng, Qiang ;
Tse, Gary M. K. .
MEDICINAL RESEARCH REVIEWS, 2008, 28 (06) :954-974
[8]   Hormone replacement therapy and lung cancer risk in Chinese [J].
Chen, Kuan-Yu ;
Hsiao, Chin-Fu ;
Chang, Gee-Chen ;
Tsai, Yin-Huang ;
Su, Wu-Chou ;
Perng, Reury-Perng ;
Huang, Ming-Shyan ;
Hsiung, Chao A. ;
Chen, Chien-Jen ;
Yang, Pan-Chyr .
CANCER, 2007, 110 (08) :1768-1775
[9]   Oestrogen plus progestin and lung cancer in postmenopausal women (Women's Health Initiative trial): a post-hoc analysis of a randomised controlled trial [J].
Chlebowski, Rowan T. ;
Schwartz, Ann G. ;
Wakelee, Heather ;
Anderson, Garnet L. ;
Stefanick, Marcia L. ;
Manson, JoAnn E. ;
Rodabough, Rebecca J. ;
Chien, Jason W. ;
Wactawski-Wende, Jean ;
Gass, Margery ;
Kotchen, Jane Morley ;
Johnson, Karen C. ;
O'Sullivan, Mary Jo ;
Ockene, Judith K. ;
Chen, Chu ;
Hubbell, F. Allan .
LANCET, 2009, 374 (9697) :1243-1251
[10]   Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women [J].
Cote, Michele L. ;
Yoo, Wonsuk ;
Wenzlaff, Angela S. ;
Prysak, Geoffrey M. ;
Santer, Susan K. ;
Claeys, Gina B. ;
Van Dyke, Alison L. ;
Land, Susan J. ;
Schwartz, Ann G. .
CARCINOGENESIS, 2009, 30 (04) :626-635