Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans

被引：77

作者：

Brys, Kristel ^{[1
]}

Vanfleteren, Jacques R. ^{[1
]}

Braeckman, Bart P. ^{[1
]}

机构：

[1] Univ Ghent, Dept Biol, B-9000 Ghent, Belgium

来源：

EXPERIMENTAL GERONTOLOGY | 2007年 / 42卷 / 09期

关键词：

rate-of-living hypothesis; oxidative damage hypothesis; Caenorhabditis elegans; daf-2(e1370);

D O I：

10.1016/j.exger.2007.02.004

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The integration of the rate-of-living and oxidative damage theory of aging predicts that lifespan extension is linked to low energy metabolism, low ROS production rates, low molecular damage and a slow aging rate. In the long-lived Caenorhabditis elegans Ins/IGF-1 mutant daf-2(e1370), low carbonylation levels and postponed morphological decline comply with the latter two of these predictions. However, metabolic rates in daf-2(e1370) refute the rate-of-living theory. The apparent contradiction between increased ROS generation and long lifespan in daf-2(e1370) is reconciled by an enhanced stress defense, acknowledging oxidative damage as a probable cause of aging. (c) 2007 Elsevier Inc. All rights reserved.

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收藏

页码：845 / 851

页数：7

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