Protein oxidation during aging of the nematode Caenorhabditis elegans

被引：41

作者：

Ishii, N ^{[1
]}

Goto, S

Hartman, PS

机构：

[1] Tokai Univ, Sch Med, Dept Mol Life Sci, Kanagawa 2591193, Japan

[2] Toho Univ, Sch Pharmaceut Sci, Dept Biochem, Chiba 2748510, Japan

[3] Texas Christian Univ, Dept Biol, Ft Worth, TX 76129 USA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2002年 / 33卷 / 08期

关键词：

protein oxidation; aging; C elegans; age-1; daf-2; mev-1; energy metabolism; free radicals;

D O I：

10.1016/S0891-5849(02)00857-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nematode Caenorhabditis elegans has proven a robust genetic model for studies of aging, including the roles of oxidative stress and protein damage. In this review, we focus on the genetics of select long-lived (e.g., age-1, daf-2, daf-16) and short-lived (e.g., mev-1) mutants that have proven useful in revealing the relationships that exist among oxidative stress, life span, and protein oxidation. The former are known to control an insulin/IGF-1-like pathway in C. elegans, while the latter affect mitochondrial function. (C) 2002 Elsevier Science Inc.

引用

页码：1021 / 1025

页数：5

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