Protein oxidation during aging of the nematode Caenorhabditis elegans

被引：41

作者：

Ishii, N ^{[1
]}

Goto, S

Hartman, PS

机构：

[1] Tokai Univ, Sch Med, Dept Mol Life Sci, Kanagawa 2591193, Japan

[2] Toho Univ, Sch Pharmaceut Sci, Dept Biochem, Chiba 2748510, Japan

[3] Texas Christian Univ, Dept Biol, Ft Worth, TX 76129 USA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2002年 / 33卷 / 08期

关键词：

protein oxidation; aging; C elegans; age-1; daf-2; mev-1; energy metabolism; free radicals;

D O I：

10.1016/S0891-5849(02)00857-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nematode Caenorhabditis elegans has proven a robust genetic model for studies of aging, including the roles of oxidative stress and protein damage. In this review, we focus on the genetics of select long-lived (e.g., age-1, daf-2, daf-16) and short-lived (e.g., mev-1) mutants that have proven useful in revealing the relationships that exist among oxidative stress, life span, and protein oxidation. The former are known to control an insulin/IGF-1-like pathway in C. elegans, while the latter affect mitochondrial function. (C) 2002 Elsevier Science Inc.

引用

页码：1021 / 1025

页数：5

共 42 条

[21] AGING IN NEMATODE CAENORHABDITIS-ELEGANS - MAJOR BIOLOGICAL AND ENVIRONMENTAL-FACTORS INFLUENCING LIFE-SPAN [J].

KLASS, MR .

MECHANISMS OF AGEING AND DEVELOPMENT, 1977, 6 (06) :413-429

[22] AGING AND RESISTANCE TO OXIDATIVE DAMAGE IN CAENORHABDITIS-ELEGANS [J].

LARSEN, PL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (19) :8905-8909

[23]

LARSEN PL, 1995, GENETICS, V139, P1567

[24]

LEVINE RL, 1990, METHOD ENZYMOL, V186, P464

[25] Oxidative modification of proteins during aging [J].

Levine, RL ;

Stadtman, ER .

EXPERIMENTAL GERONTOLOGY, 2001, 36 (09) :1495-1502

[26] Genetic analysis of ageing: Role of oxidative damage and environmental stresses [J].

Martin, GM ;

Austad, SN ;

Johnson, TE .

NATURE GENETICS, 1996, 13 (01) :25-34

[27] Extension of life-span with superoxide dismutase/catalase mimetics [J].

Melov, S ;

Ravenscroft, J ;

Malik, S ;

Gill, MS ;

Walker, DW ;

Clayton, PE ;

Wallace, DC ;

Malfroy, B ;

Doctrow, SR ;

Lithgow, GJ .

SCIENCE, 2000, 289 (5484) :1567-1569

[28] A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans [J].

Morris, JZ ;

Tissenbaum, HA ;

Ruvkun, G .

NATURE, 1996, 382 (6591) :536-539

[29] The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans [J].

Murakami, S ;

Johnson, TE .

CURRENT BIOLOGY, 2001, 11 (19) :1517-1523

[30] Vitellogenin-6 is a major carbonylated protein in aged nematode, Caenorhabditis elegans [J].

Nakamura, A ;

Yasuda, K ;

Adachi, H ;

Sakurai, Y ;

Ishii, N ;

Goto, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 264 (02) :580-583

← 1 2 3 4 5 →