Use of pyrosequencing to detect clinically relevant polymorphisms in dihydropyrimidine dehydrogenase

被引:19
作者
Ahluwalia, R [1 ]
Freimuth, R [1 ]
McLeod, HL [1 ]
Marsh, S [1 ]
机构
[1] Washington Univ, Sch Med, Div Oncol, St Louis, MO 63110 USA
关键词
D O I
10.1373/49.10.1661
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
[No abstract available]
引用
收藏
页码:1661 / 1664
页数:4
相关论文
共 20 条
[1]  
Ando Y, 2000, CANCER RES, V60, P6921
[2]   Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine [J].
Black, AJ ;
McLeod, HL ;
Capell, HA ;
Powrie, RH ;
Matowe, LK ;
Pritchard, SC ;
Collie-Duguid, ESR ;
Reid, DM .
ANNALS OF INTERNAL MEDICINE, 1998, 129 (09) :716-718
[3]   The essence of SNPs [J].
Brookes, AJ .
GENE, 1999, 234 (02) :177-186
[4]   Known variant DPYD alleles do not explain DPD deficiency in cancer patients [J].
Collie-Duguid, ESR ;
Etienne, MC ;
Milano, G ;
McLeod, HL .
PHARMACOGENETICS, 2000, 10 (03) :217-223
[5]   Complex promoter and coding region β2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness [J].
Drysdale, CM ;
McGraw, DW ;
Stack, CB ;
Stephens, JC ;
Judson, RS ;
Nandabalan, K ;
Arnold, K ;
Ruano, G ;
Liggett, SB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (19) :10483-10488
[6]   Drug therapy - Pharmacogenomics - Drug disposition, drug targets, and side effects [J].
Evans, WE ;
McLeod, HL .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (06) :538-549
[7]   Allele and genotype frequencies of polymorphic cytochromes P450 (CYP2C9, CYP2C19, CYP2E1) and dihydropyrimidine dehydrogenase (DPYD) in the Egyptian population [J].
Hamdy, SI ;
Hiratsuka, M ;
Narahara, K ;
El-Enany, M ;
Moursi, N ;
Ahmed, MSE ;
Mizugaki, M .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2002, 53 (06) :596-603
[8]   UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity [J].
Iyer L. ;
Das S. ;
Janisch L. ;
Wen M. ;
Ramírez J. ;
Karrison T. ;
Fleming G.F. ;
Vokes E.E. ;
Schilsky R.L. ;
Ratain M.J. .
The Pharmacogenomics Journal, 2002, 2 (1) :43-47
[9]   Notes from the SNP vs. haplotype front [J].
Judson, R ;
Stephens, JC .
PHARMACOGENOMICS, 2001, 2 (01) :7-10
[10]   PHARMACOGENETICS OF ACUTE AZATHIOPRINE TOXICITY - RELATIONSHIP TO THIOPURINE METHYLTRANSFERASE GENETIC-POLYMORPHISM [J].
LENNARD, L ;
VANLOON, JA ;
WEINSHILBOUM, RM .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1989, 46 (02) :149-154