Isolation and structure of phakellistatin 14 from the western pacific marine sponge Phakellia sp.

被引：39

作者：

Pettit, GR

Tan, R

机构：

[1] Arizona State Univ, Inst Canc Res, Tempe, AZ 85287 USA

[2] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 01期

关键词：

D O I：

10.1021/np040092w

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new cycloheptapeptide, phakellistatin 14, was isolated in 8.8 x 10(-7)% yield from Phakellia sp., a marine sponge from Chuuk, Federated States of Micronesia. The structure (1), cyclo-Phe-beta-OMe-Asp-Ala-Met(SO)-Ala-Ile-Pro, was elucidated by 1D and 2D NMR spectral analyses augmented by HRFABMS. The chirality of each amino acid unit was determined to be S using chiral HPLC methods. Phakellistatin 14 showed cancer cell growth inhibitory activity (ED50 5 mug/mL) against the murine lymphocytic leukemia P388 cell line.

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页码：60 / 63

页数：4

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