Intracellular delivery of quantum dots tagged antisense oligodeoxynucleotides by functionalized multiwalled carbon nanotubes

被引：131

作者：

Jia, Nengqin

Lian, Qiong

Shen, Hebei

Wang, Chen

Li, Xingyu

Yang, Zhongnan

机构：

[1] Shanghai Normal Univ, Life & Environm Sci Coll, Dept Chem, Shanghai 200234, Peoples R China

[2] Shanghai Normal Univ, Life & Environm Sci Coll, Dept Biol, Shanghai 200234, Peoples R China

来源：

NANO LETTERS | 2007年 / 7卷 / 10期

关键词：

D O I：

10.1021/nl071114c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

With the goal of identifying an improved delivery scheme for intracellular tracking and anticancer therapy, we explored a novel double functionalization of a carbon nanotube delivery system containing antisense oligodeoxynucleotides (ASODNs) as a therapeutic gene and CdTe quantum dots as fluorescent labeling probes via electrostatically layer-by-layer assembling. This is the first time that we used mercaptoacetic acid-capped CdTe quantum dots as fluorescent labeling probes for clearly tracking the intracellular transport and evaluating delivery efficiency of ASODNs by functionalized multiwalled carbon nanotubes (MWNTs).

引用

收藏

页码：2976 / 2980

页数：5

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