Effects of fucoidan on chronic renal failure in rats

被引：7

作者：

Zhang, QB

Li, Z

Xu, ZH ^{[1
]}

Niu, XZ

Zhang, H

机构：

[1] Acad Sinica, Inst Oceanol, Qingdao 266071, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

来源：

PLANTA MEDICA | 2003年 / 69卷 / 06期

关键词：

Laminaria japonica; Laminariaceae; fucoidan; chronic renal failure; serum creatinine; serum urea nitrogen;

D O I：

暂无

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The effects of fucoidan on chronic renal failure (CRF) were investigated in vivo in a subtotal nephrectomy CRF model and a cryoinjury induced CRF model in rats. Fucoidan showed renoprotective effects in both models. Fucoidan (100 or 200 mg/kg, orally) significantly decreased elevated serum creatinine and urea nitrogen levels. Histopathological changes of renal. tubules and interstitium were markedly alleviated by fucoidan and the mesangial areas were also greatly reduced. The activities of fucoidan were dose-dependent.

引用

页码：537 / 541

页数：5

共 18 条

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