A palladium-catalyzed regiospecific synthesis of N-aryl Benzimidazoles

被引：126

作者：

Zheng, Nan ^{[1
]}

Anderson, Kevin W. ^{[1
]}

Huang, Xiaohua ^{[1
]}

Nguyen, Hanh Nho ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 39期

关键词：

amination; heterocycles; N-aryl benzimidazole; palladium;

D O I：

10.1002/anie.200702542

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Highly tolerated: A catalytic method employing [Pd2(dba)3] and XPhos or RuPhos permits the efficient synthesis of N-aryl benzimidazoles in regioisomerically pure form starting from ortho-halo-anilides (see scheme), and tolerates a wide range of functional groups, dba = trans,trans-dibenzylideneacetone. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7509 / 7512

页数：4

共 24 条

[1]

Anderson K.W., 2006, ANGEW CHEM, V118, P6673, DOI [10.1002/ange.200601612, DOI 10.1002/ANGE.200601612]

[2] Monodentate phosphines provide highly active catalysts for Pd-catalyzed C-N bond-forming reactions of heteroaromatic halides/amines and (H)N-heterocycles [J].