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Role of Fas-mediated cell death in the regulation of immune responses

被引：213
作者：
vanParijs, L
Abbas, AK
机构：
[1] Division of Immunology, Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115
来源：
CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 03期
关键词：
D O I：
10.1016/S0952-7915(96)80125-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interaction of the cell-surface molecule Pas (CD95 APO-1) with its specific ligand triggers apoptotic death of T and B lymphocytes. This pathway is important for eliminating self-reactive lymphocytes and thus preventing autoimmunity. Pas is also involved in controlling injurious lymphocyte reactions in immunologically 'privileged' tissues, and may provide a strategy for reducing graft rejection.
引用
收藏
页码：355 / 361
页数：7
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